Celsion Corporation (NASDAQ:CLSN) has announced updated results from its retrospective analysis of the 701-patient HEAT Study of ThermoDox, its heat-activated liposomal encapsulation of doxorubicin, in combination with radiofrequency ablation (RFA) in primary liver cancer.
As of June 30, the latest quarterly Overall Survival (OS) analysis demonstrated that in 41% of the study patients, the combination of ThermoDox and optimized RFA provided a 57% improvement in OS compared to optimized RFA alone. Shares of CLSN are up $0.26, or 7.67%, at $3.65 within a 52-week range of $2.82 – $6.62.
“The post-hoc HEAT Study data is striking in that it has consistently shown a marked OS benefit for ThermoDox plus optimized RFA versus RFA alone in each of the quarterly data sweeps, with this 5th, and final data set demonstrating that this survival benefit is statistically significant,” stated Michael Tardugno, Celsion’s President and Chief Executive Officer. “This impressive clinical data set, together with prospective supportive preclinical study results and multivariate Cox Regression Analyses, reinforces our confidence in the protocol for our Phase III OPTIMA Study in primary liver cancer, which is evaluating ThermoDox in combination with a standardized RFA protocol in primary liver cancer.”
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